Nitrazepam continues to be related to severe hepatic disorders, much like other nitrobenzodiazepines. Nitrobenzodiazepines such as nitrazepam, nimetazepam, flunitrazepam, and clonazepam tend to be more harmful towards the liver than other benzodiazepines as they are metabolically activated by CYP3A4 which can lead to cytotoxicity.The 50 %-lifetime